A bibliometric analysis of penile cancer research

Análisis bibliométrico de la investigación del cáncer de pene

Background: The purpose of this study is to investigate the collaboration among countries, institutions and authors in the field of penile cancer research, as well as to identify the current hot topics in this area. Methods: Papers about penile cancer were retrieved from the Web of Science Core Collection (WoSCC). Bibliometric analyses were conducted using VOSviewer and CiteSpace to evaluate collaborations between different keywords, institutions, authors and countries in network maps. Results: 2891 articles related to penile cancer were included. The number of publications were gradually increasing the from 1991 to 2023. Journal of Urology (196 papers) owned the highest number of publications and Journal of Urology was the most co-cited journal. Simon Horenblas was identified as the top productive author with 98 papers and received a large number of citations (5383 co-citations) over the past decades. The United States emerged as the leading publisher in this field with 932 papers published. Cooperation between countries and between institutions was observed. The hot topics included matters mainly related to squamous-cell carcinoma, cancer, penile cancer, erectile dysfunction, men, penis and lymphadenectomy. Conclusions: This study utilized visualization tools to create a knowledge map of penile cancer research which provides new insights into its time series development context, research hotspots, knowledge network structure and major scholars’ contributions in this field.

Resumen

Antecedentes: El propósito de este estudio es investigar la colaboración entre países, instituciones y autores en el campo de la investigación del cáncer de pene, así como identificar los temas candentes actuales en esta área. Métodos: Los documentos sobre el cáncer de pene se recuperaron del Web of Science Core Collection (WoSCC). Se realizaron análisis bibliométricos utilizando VOSviewer y CiteSpace para evaluar colaboraciones entre diferentes palabras clave, instituciones, autores y países en mapas de red. Resultados: Se incluyeron 2891 artículos relacionados con el cáncer de pene. El número de publicaciones fue aumentando gradualmente de 1991 a 2023. Journal of Urology (196 artículos) poseía el mayor número de publicaciones y Journal of Urology fue la revista más cocitada. Simon Horenblas fue identificado como el autor más productivo con 98 artículos y recibió un gran número de citas (5383 co-citas) en las últimas décadas. Estados Unidos emergió como la principal casa editorial en este campo con 932 artículos publicados. Se observó la cooperación entre países e instituciones instituciones. Los temas más importantes incluyeron asuntos relacionados principalmente con el carcinoma de células escamosas, el cáncer, el cáncer de pene, la disfunción eréctil, los hombres, el pene y la linfadenectomía. Conclusiones: Este estudio utilizó herramientas de visualización para crear un mapa de conocimiento de la investigación del cáncer de pene que proporciona nuevos conocimientos sobre su contexto de desarrollo de series de tiempo, los puntos de interés de la investigación, la estructura de la red de conocimiento y las contribuciones de los principales investigadores en este campo.

Penile neoplasms; Erectile dysfunction; Bibliometric; Network maps; Squamous-cell carcinoma

Palabras Clave

Neoplasias del pene; Disfunción eréctil; Bibliometric; Network maps; Squamous-cell carcinoma

[1] Thomas A, Necchi A, Muneer A, Tobias-Machado M, Tran ATH, Van Rompuy AS, et al. Penile cancer. Nature Reviews Diseases Primers. 2021; 7: 11.

[2] Engelsgjerd JS, Leslie SW, LaGrange CA. Penile cancer and penile intraepithelial neoplasia. StatPearls: Treasure Island (FL). 2024.

[3] Siegel RL, Giaquinto AN, Jemal A. Cancer statistics, 2024. CA: A Cancer Journal for Clinicians. 2024; 74: 12–49.

[4] Moch H, Amin MB, Berney DM, Compérat EM, Gill AJ, Hartmann A, et al. The 2022 World Health Organization classification of tumours of the urinary system and male genital organs-part a: renal, penile, and testicular tumours. European Urology. 2022; 82: 458–468.

[5] Bologna E, Licari LC, Franco A, Ditonno F, Manfredi C, De Nunzio C, et al. Characteristics, trends, and management of penile cancer in the United States: a population-based study. Urologic Oncology. 2024; 42: 334.e11–334.e18.

[6] Zyoud SH, Alalalmeh SO, Hegazi OE, Shakhshir M, Abushamma F, Al-Jabi SW. An examination of global research trends for exploring the associations between the gut microbiota and nonalcoholic fatty liver disease through bibliometric and visualization analysis. Gut Pathogens. 2024; 16: 31.

[7] Zhou Y, Ma C. Bibliometric trends in priapism research publications. Journal of Men’s Health. 2022; 18: 38–48.

[8] Chen C. CiteSpace II: detecting and visualizing emerging trends and transient patterns in scientific literature. Journal of the American Society for Information Science and Technology. 2006; 57: 359–377.

[9] Boshart M, Gissmann L, Ikenberg H, Kleinheinz A, Scheurlen W, zur Hausen H. A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer. The EMBO Journal. 1984; 3: 1151–1157.

[10] Baumgarten A, Chipollini J, Yan S, Ottenhof SR, Tang DH, Draeger D, et al. Penile sparing surgery for penile cancer: a multicenter international retrospective cohort. The Journal of Urology. 2018; 199: 1233–1237.

[11] Tang DH, Yan S, Ottenhof SR, Draeger D, Baumgarten AS, Chipollini J, et al. Laser ablation as monotherapy for penile squamous cell carcinoma: a multi-center cohort analysis. Urologic Oncology. 2018; 36: 147–152.

[12] Tang DH, Yan S, Ottenhof SR, Draeger D, Baumgarten AS, Chipollini J, et al. Glansectomy as primary management of penile squamous cell carcinoma: an international study collaboration. Urology. 2017; 109: 140–144.

[13] Suarez-Ibarrola R, Cortes-Telles A, Miernik A. Health-related quality of life and sexual function in patients treated for penile cancer. Urologia Internationalis. 2018; 101: 351–357.

[14] Yu C, Hequn C, Longfei L, Minfeng C, Zhi C, Feng Z, et al. Sexual function after partial penectomy: a prospectively study from China. Scientific Reports. 2016; 6: 21862.

[15] Cleaveland P, Lau M, Parnham A, Murby B, Ashworth D, Manohoran P, et al. Testing the feasibility of Sentimag/sienna+ for detecting inguinal sentinel nodes in penile cancer (Sentipen): an eUROGEN and national cancer research institute trial. European Urology. 2019; 76: 874–875.

[16] Matin SF, Cormier JN, Ward JF, Pisters LL, Wood CG, Dinney CP, et al. Phase 1 prospective evaluation of the oncological adequacy of robotic assisted video-endoscopic inguinal lymphadenectomy in patients with penile carcinoma. BJU International. 2013; 111: 1068–1074.

[17] Porcellato I, Mecocci S, Brachelente C, Cappelli K, Armando F, Tognoloni A, et al. PD-L1/PD-1 and CTLA-4 expression in equine penile squamous cell carcinomas. Animals. 2021; 11: 2121.

[18] Ahmed ME, Falasiri S, Hajiran A, Chahoud J, Spiess PE. The immune microenvironment in penile cancer and rationale for immunotherapy. Journal of Clinical Medicine. 2020; 9: 3334.

[19] Stroie FA, Houlihan MD, Kohler TS. Sexual function in the penile cancer survivor: a narrative review. Translational Andrology and Urology. 2021; 10: 2544–2553.

[20] Rose KM, Pham R, Zacharias NM, Ionescu F, Paravathaneni M, Marchetti KA, et al. Neoadjuvant platinum-based chemotherapy and lymphadenectomy for penile cancer: an international, multi-institutional, real-world study. Journal of the National Cancer Institute. 2024; 116: 966–973.

[21] Chahoud J, Yu X, Necchi A, Spiess PE. TP53 mutations emerge as a critical biomarker in penile cancer, superseding human papillomavirus status. European Urology. 2024; 86: 128–129.